The hotel offers a central location making other areas easily accessible. Those staying at the NH Ciudad de Santiago will be able to visit the historical areas as well as the main shopping and entertainment areas of the city. Guests will find places to experience the culture and nightlife of the city as well. The subway is only a short walk from the NH Ciudad de Santiago. Guests will find many forms of public transportation that can help them get around the city to areas that are not within walking distance of the hotel. The airport is only 20 km from the hotel and takes about 15 minutes to reach.

The hotel has 122 rooms on the property. Guests will find that the rooms at the NH Ciudad de Santiago include amenities such as minibars, Internet connections, phones, a safe in the room, and a sofa bed.

Guests staying at the NH Ciudad de Santiago will be able to dine at the onsite restaurant on a variety of cuisine. The hotel also offers an indoor swimming pool and a gym for those who want to keep fit.